
职务/职称、学历:湖南医304am永利集团副主任药师、博士研究生
电子邮箱:caoyuhong@zju.edu.cn
研究领域:肿瘤多药耐药研究、药物—靶点相互作用分析、药物心脏毒性评价
一、学习及工作经历
2024.4—至今 湖南医304am永利集团副主任药师
2023.10--2024.4 浙江省食品药品检验研究院药师
2021.9--2023.10 浙江大学医学部,博士后
2018.09--2021.07 海军军医大学,药物分析,博士
2012.09--2015.06 河北大学,分析化学,硕士
2008.09-2012.07 安庆师范大学,化学工程,本科
二、讲授课程
《分析化学》《药物分析》《中药分析》
三、代表性研究成果
1.教科研项目
(1)国家自然科学基金青年项目,82204348,P-糖蛋白抑制剂高效筛选方法的建立及逆转阿霉素诱导的多药耐药和心脏毒性研究,2023.01-2025.12,主持。
(2)浙江省药物安全性评价技术研究重点实验室开放课题,基于人诱导多能干细胞衍生心肌细胞的抗精神病药物心脏毒性评价及机制研究,2022.01-2024.12,主持。
2.教科研论文
(1)Cao Y, et al. Screening potential P-glycoprotein inhibitors by combination of a detergent-free membrane protein extraction with surface plasmon resonance biosensor[J].Acta Pharm Sin B.2022, 12(7):3113-3123.
(2)Cao Y,et al. The Effects of Traditional Chinese Medicine on P-Glycoprotein-Mediated Multidrug Resistance and Approaches for Studying the Herb-P-Glycoprotein Interactions[J].Drug Metab Dispos.2020 ,48(10):972-979)
(3)Cao Y,et al.Surface plasmon resonance biosensor combined with lentiviral particle stabilization strategy for rapid and specific screening of P-Glycoprotein ligands.Anal Bioanal Chem[J].2021, 413 (7), 2021-2031.
(4)Cao Ye,t al. A Mechanistic Study of Blood-brain Barrier Transport of the Major Active Constituents of Salvia miltiorrhiza Bunge[J].ACS Chem Neurosci, 2023,14 (4), 766-772.
(5) Shi Y, Cai Y,Cao Y. Recent advances in microfluidic technology and applications for anti-cancer drug screening[J].TrAC Trends in Analytical Chemistry, 2020, 134:116118.
(6)Cao Y,et al. Generation of a TRPV1 knockout human pluripotent stem cell line (WAe009-A-U) using CRISPR/Cas9[J].Stem Cell Res, 2023, 72: 103202.
(7)曹雨虹.生物样品中神经递质的定量测定及其应用研究进展.色谱, 2019,37(03):29-37.
(8)Cao Y,et al.Tetrandrine reversed P-gp-induced multidrug resistance in MCF-7/ADR xenograft model: pharmacokinetic and pharmacological study.Journal of Ethnopharmacology, under review,共一.
(9) Cao Y, et al. The comprehensive evaluation and mechanism study of cardiotoxicity induced by antipsychotics based on iPSC-CM.已完成论文撰写,拟投Acta Pharm Sin B.
四、荣誉
第九届、第十一届普析杯药分大会优秀论文评选交流会二等奖